merck millipore,默克密理愽
  • merck millipore,默克密理博,AB9208,Anti-DARPP-32 Antibody, phosphoThr75

  • merck millipore,默克密理博,AB9208,Anti-DARPP-32 Antibody, phosphoThr75

    产品名称：Anti-DARPP-32 Antibody, phosphoThr75
    产品型号：AB9208
    Detect DARPP-32 using this Anti-DARPP-32 Antibody, phosphoThr75 validated for use in WB.

    merck millipore,默克密理博,AB9208,Anti-DARPP-32 Antibody, phosphoThr75

  • 产品介绍
  • merck millipore,默克密理博,AB9208,Anti-DARPP-32 Antibody, phosphoThr75

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB9208
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-DARPP-32 Antibody, phosphoThr75
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg per mL BSA with 50% glycerol.
    应用
    应用 Detect DARPP-32 using this Anti-DARPP-32 Antibody, phosphoThr75 validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1,000. The antibody recognizes the ~34 kD DARPP-32 protein phosphorylated at Thr75 protein in rat caudate lysate prepared from caudate slices that had been incubated in the absence and presence of okadaic acid. The labeling by the antibody to DARPP-32 Thr75 is markedly increased by the okadaic acid treatment.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide from human/mouse DARPP-32, phosphoThr75.
    表位 phosphoThr75
    宿主 Rabbit
    特异性 DARPP-32, phosphoThr75.
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_181505.2
    • NM_032192.2
    Entrez基因汇总 Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 [PubMed 2191086]) that also express dopamine D1 receptors (Walaas and Greengard, 1984 [PubMed 6319627]). The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions (Halpain et al., 1990 [PubMed 2153935]). Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 [PubMed 6319627]); phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 [PubMed 6087160]). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et al., 1990 [PubMed 2153935]).[supplied by OMIM]
    基因符号
    • FLJ20940
    • PPP1R1B
    • DARPP32
    • DARPP-32
    修改
    • Phosphorylation
    UniProt编号
    • Q9UD71
    UniProt汇总 FUNCTION: SwissProt: Q9UD71 # Inhibitor of protein-phosphatase 1.
    SIZE: 204 amino acids; 22963 Da
    SUBCELLULAR LOCATION: Cytoplasm.
    PTM: Dopamine- and cyclic AMP-regulated neuronal phosphoprotein. & Phosphorylation of Thr-34 is required for activity (By similarity).
    SIMILARITY: SwissProt: Q9UD71 ## Belongs to the protein phosphatase inhibitor 1 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C to -80°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB9208,Anti-DARPP-32 Antibody, phosphoThr75

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