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品种反应性 主要应用 宿主 格式 抗体类型 R, B, H, M WB Sh Purified Polyclonal Antibody 描述 产品目录编号 AB9016 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Chx10 Antibody, NT Alternate Names - C. Elegans ceh-10 Homeo Domain Containing Homolog
- Hox-10
- Ocular Retardation
产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS containing 0.08% sodium azide. 应用 应用 Detect Chx10 using this Anti-Chx10 Antibody, N-terminus validated for use in WB. 主要应用 - Western Blotting
应用说明 Immunoblotting: 0.5-1.0 μg/mL. Reacts with the 46 kD protein in rat and mouse retinal tissue lysate.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Recombinant human Chx10 protein, N-terminal. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Sheep 特异性 Chx10 品种反应性 RatBovineHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_182894.2
基因符号 - RET1
- VSX2
- HOX10
- MCOPCB3
- CHX10
- MCOP2
UniProt编号 - P58304
UniProt汇总 FUNCTION: SwissProt: P58304 # Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity).
SIZE: 361 amino acids; 39411 Da
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Abundantly expressed in retinal neuroblasts during eye development and in the inner nuclear layer of the adult retina. Within this layer, expression is stronger in the outer margin where bipolar cells predominate.
DISEASE: SwissProt: P58304 # Defects in VSX2 are the cause of microphthalmia with cataracts and iris abnormalities [MIM:610092]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. It is a cause of congenital blindness. & Defects in VSX2 are the cause of isolated microphthalmia with coloboma 3 (MCOPCB3) [MIM:610092]; also known as isolated colobomatous microphthalmia 3. & Defects in VSX2 are the cause of isolated microphthalmia 2 (MCOP2) [MIM:610093]; also known as clinical anophthalmia.
SIMILARITY: SwissProt: P58304 ## Belongs to the paired homeobox family. & Contains 1 CVC domain. & Contains 1 homeobox DNA-binding domain. & Contains 1 OAR domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 250 µg
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