merck millipore,默克密理愽
  • merck millipore,默克密理博,23-024M,p27 Protein complex, activated, 250 µg

  • merck millipore,默克密理博,23-024M,p27 Protein complex, activated, 250 µg

    产品名称：p27 Protein complex, activated, 250 µg
    产品型号：23-024M
    Activated complex of three full length, recombinant human proteins: p27, Cyclin E1 & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays.

    merck millipore,默克密理博,23-024M,p27 Protein complex, activated, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,23-024M,p27 Protein complex, activated, 250 µg

    重要规格表

    主要应用 品种 级联部件
    EAHumanSubstrate
    描述
    产品目录编号 23-024M
    品牌系列 Upstate
    商名
    • Upstate
    描述 p27 Protein complex, activated, 250 µg
    长描述 Complex of N-terminal c-Myc-tagged, recombinant human p27 full length, 6His-tagged, recombinant human Cyclin E1 full length and untagged, recombinant human CDK2 full length, co-expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography. Phosphorylated in vitro using CDK2/Cyclin E1.
    Alternate Names
    • Kip1
    • p27<sup>kip1</sup>
    • Cyclin-dependent kinase inhibitor 1B
    背景信息 p27 is an important regulator of cell cycle progression, involved in G1 arrest. It is a potent inhibitor of cyclin E1- and cyclin A-CDK2 complexes and a positive regulator of cyclin D-dependent kinases such as CDK4. The degradation of this protein, which is triggered by its CDK-dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Decreased levels of p27 are found in various epithelial tumours originating from lung, breast, colon, ovary, oesophagus, thyroid and prostate. Defects in the gene encoding p27 (CDKN1B) are the cause of multiple endocrine neoplasia type 4 (MEN4) an inherited cancer of the thyroid.
    应用
    应用 Activated complex of three full length, recombinant human proteins: p27, Cyclin E1 & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays.
    主要应用
    • Enzyme Assay
    生物信息
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    级联部件 Substrate
    Entrez基因编号
    • NM_001238 (Cyclin E1) (GenBank Number)
    • BC001971(p27) (GenBank Number)
    • NM_001798 (CDK2) (GenBank Number)
    纯化方法 Purified using immobilized metal affinity chromatography.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 250 µg

    merck millipore,默克密理博,23-024M,p27 Protein complex, activated, 250 µg

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