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品种反应性 主要应用 宿主 格式 抗体类型 Chp, H, M, R IH(P) Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB6066 描述 Anti-Fibulin-6 Antibody Alternate Names - Fibulin-6
- Hemicentin-1
背景信息 Fibulin-6 (also known as Hemicentin-1) has been linked to age-related macular degeneration. Deregulation of fibulin-6 has been linked to damage of the architecture of the salivary gland in Sjögren's syndrome. Fibulin-6 interacts with ARMS2, which are involved in proper matrix function. 产品信息 格式 Affinity Purified 控制 - Elastic fibers of human eye tissue or the external laminating membrane of mouse eye tissue.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Fibulin-6 Antibody is an antibody against Fibulin-6 for use in IH(P). 主要应用 - Immunohistochemistry (Paraffin)
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Fibulin-6. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 ChimpanzeeHumanMouseRat Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat.
Predicted to react with Chimpanzee based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_114141
Entrez基因汇总 Summary: This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration. [provided by RefSeq]. 基因符号 - FIBL6
- FIBL-6
- HMCN1
纯化方法 Affinity Purified UniProt编号 - Q96RW7
UniProt汇总 SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix › basement membrane (by similarity).
TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed in skin fibroblasts and retinal pigment epithelium (RPE) cells.
INVOLVEMENT IN DISEASE: Defects in HMCN1 are a cause of age-related macular degeneration type 1 (ARMD1) [MIM:603075]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
SEQUENCE SIMILARITIES: Contains 7 EGF-like domains. Contains 44 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 nidogen G2 beta-barrel domain. Contains 6 TSP type-1 domains. Contains 1 VWFA domain.
SEQUENCE CAUTION: The sequence BAB71154.1 differs from that shown. Reason: Frameshift at position 657. The sequence BAB71216.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by immunohistochemistry on human or mouse eye tissues.
Immunohistochemistry (paraffin) Analysis: A 1:400 dilution of this antibody was used to detect Fibulin-6 in the elastic fibers of human eye tissue or the external laminating membrane of mouse eye tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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