merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5930,Anti-Potassium Channel ERG1 Antibody, CT

  • merck millipore,默克密理博,AB5930,Anti-Potassium Channel ERG1 Antibody, CT

    产品名称：Anti-Potassium Channel ERG1 Antibody, CT
    产品型号：AB5930
    Anti-Potassium Channel ERG1 Antibody, C-terminus detects level of Potassium Channel ERG1 & has been published & validated for use in IC, IH, IP & WB.

    merck millipore,默克密理博,AB5930,Anti-Potassium Channel ERG1 Antibody, CT

  • 产品介绍
  • merck millipore,默克密理博,AB5930,Anti-Potassium Channel ERG1 Antibody, CT

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWB, ICC, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5930
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Potassium Channel ERG1 Antibody, CT
    Alternate Names
    • RERG1
    • Ether-a-go-go-related Gene Product
    • HERG1
    • MERG1
    背景信息 ERG1 encodes the pore forming alpha subunit of the voltage-gated channels that conduct the rapid delayed rectifier potassium current, which leads to termination of the cardiac ventricular action potential. A large number of commercially available therapeutic agents (antiarrhythmics, antihistamines, antibiotics and antidepressants) have been shown to preferentially block ERG1 and cause a disorder of cardiac action potential depolarization that predisposes affected individuals to ventricular arrhythmia and sudden death.
    产品信息
    格式 Affinity Purified
    控制
    • Positive control tissue: Heart
    演示 Liquid in PBS with 0.1% sodium azide.
    应用
    应用 Anti-Potassium Channel ERG1 Antibody, C-terminus detects level of Potassium Channel ERG1 & has been published & validated for use in IC, IH, IP & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Immunoblotting: 5 μg/mL

    Immunocytochemistry

    Immunohistochemistry on 4% paraformaldehyde fixed tissues.

    Immunoprecipitation

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to the C-terminus of ERG1 (aa 1145-1159 of HERG1).
    表位 C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 ERG1 protein. By western blot, antibody recognizes bands at 175 and 205 kDa (glycosylated) or 135 and 165 kDa (deglycosylated).
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_172057.1
    • NM_000238.2
    • NM_172056.1
    Entrez基因汇总 This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.
    基因符号
    • ERG
    • KCNH2
    • ERG1
    • LQT2
    • erg1
    • HERG
    • SQT1
    • H-ERG
    • Kv11.1
    • HERG1
    • Erg1
    UniProt编号
    • Q12809
    UniProt汇总 FUNCTION: SwissProt: Q12809 # Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
    SIZE: 1159 amino acids; 126655 Da
    SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3. Interacts with ALG10B (By similarity). Heteromultimer with KCNE1 and KCNE2.
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Highly expressed in heart and brain.
    DOMAIN:SwissProt: Q12809 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    PTM: Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.
    DISEASE: SwissProt: Q12809 # Defects in KCNH2 are the cause of long QT syndrome type 2 (LQT2) [MIM:152427]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2. & Defects in KCNH2 are the cause of short QT syndrome type 1 (SQT1) [MIM:609620]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death.
    SIMILARITY: Belongs to the potassium channel family. H (Eag) subfamily. & Contains 1 cyclic nucleotide-binding domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 1 PAS (PER-ARNT-SIM) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB5930,Anti-Potassium Channel ERG1 Antibody, CT

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