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merck millipore,默克密理博,AB5609,Anti-GABA A Receptor α1 Antibody, cytoplasmic loop
产品名称：Anti-GABA A Receptor α1 Antibody, cytoplasmic loop
产品型号：AB5609
Anti-GABA A Receptor α1 Antibody, cytoplasmic loop is an antibody against GABA A Receptor α1 for use in IP & WB.
merck millipore,默克密理博,AB5609,Anti-GABA A Receptor α1 Antibody, cytoplasmic loop
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5609 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-GABA A Receptor α1 Antibody, cytoplasmic loop 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in 10 mM Hepes, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. Approximate concentration is 0.15 mg/mL. 应用 应用 Anti-GABA A Receptor α1 Antibody, cytoplasmic loop is an antibody against GABA A Receptor α1 for use in IP & WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000
Immunopreciptation: The antibody will immunoprecipitate 59% of all GABA A receptors in dodecysulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Fusion protein from the cytoplasmic loop of rat GABAA receptor alpha1 subunit. 表位 cytoplasmic loop 宿主 Rabbit 特异性 GABAA receptor alpha1 subunit, cytoplasmic loop. The apparent molecular mass of 51 kDa in rat brain membrane fractions. The antibody shows no reactivity in the forebrain of alpha1 knockout mice by Western blot. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000806.4
Entrez基因汇总 GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. 基因符号 - EJM
- GABRA1
- GABA
- ECA4
UniProt编号 - P14867
UniProt汇总 FUNCTION: SwissProt: P14867 # GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SIZE: 456 amino acids; 51802 Da
SUBUNIT: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
DISEASE: SwissProt: P14867 # Defects in GABRA1 are a cause of juvenile myoclonic epilepsy (JME) [MIM:606904]. JME is a common epileptic syndrome characterized by afebrile seizures, onset in adolescence (rather than in childhood) and myoclonic jerks. & Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4) [MIM:611136]. ECA4 is a subtype of idiopathic generalized epilepsy (IGE) characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Absence seizures may either remit or persist into adulthood.
SIMILARITY: SwissProt: P14867 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. 包装信息 数量 100 µL
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