merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5580-50UL,Anti-SCN8A Sodium Channel Antibody

  • merck millipore,默克密理博,AB5580-50UL,Anti-SCN8A Sodium Channel Antibody

    产品名称：Anti-SCN8A Sodium Channel Antibody
    产品型号：AB5580-50UL
    Detect SCN8A Sodium Channel using this Anti-SCN8A Sodium Channel Antibody validated for use in IC, IH & WB.

    merck millipore,默克密理博,AB5580-50UL,Anti-SCN8A Sodium Channel Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5580-50UL,Anti-SCN8A Sodium Channel Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, MWB, ICC, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5580-50UL
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-SCN8A Sodium Channel Antibody
    Alternate Names
    • CerIII
    • PN4
    • NaCh6
    • Sodium Channel Nav1.6
    背景信息 Voltage-gated sodium channels perform critical roles for electrical signaling in the nervous ssystem by generating action potentials in axons and dndrites. At least 10 genes encode sodium channels in mammals, but specific physiological roles that distinguish each of these isoforms are not well known. Nav1.6 is highly concentrated at notes of Ranvier of both sensory and motor axons in the peripheral nervous system and at nodes in the central nervous system. Because of its consistant and restrictied labeling, Anti-Nav1.6 (AB5580) has been used effectively as a nodes of Ranvier marker.
    产品信息
    格式 Affinity Purified
    控制
    • CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
    演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
    应用
    应用 Detect SCN8A Sodium Channel using this Anti-SCN8A Sodium Channel Antibody validated for use in IC, IH & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Western blot: (1:200) using ECL on rat brain membranes.

    Immunohistochemistry on fixed frozen sections.

    Immunocytochemistry on rat dorsal root ganglion primary culture (1:100)

    Dilutions should be made using a carrier protein such as BSA (1-3%)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Peptide corresponding to amino acids 1042-1061 from mouse (Accession number AAD20438) or rat (Accession number AAC26014) Scn8a.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Scn8a (Nav1.6). The epitope corresponds to the intracellular loop between II and III domains of Scn8a. Does not cross react with any other known proteins.

    SPECIES REACTIVITIES: It is expected that the antibody will also work on mouse (20/20) and human (19/20) due to sequence homology. Other species have not been tested.
    品种反应性 RatMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_014191.2
    基因符号
    • CerIII
    • SCN8A
    • Nav1.6
    • MED
    • NaCh6
    • PN4
    UniProt编号
    • Q9UQD0
    UniProt汇总 FUNCTION: SwissProt: Q9UQD0 # Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
    SIZE: 1980 amino acids; 225280 Da
    SUBUNIT: Interacts with NEDD4 and NEDD4L (By similarity).
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    DOMAIN: SwissProt: Q9UQD0 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
    PTM: May be ubiquitinated by NEDD4L; which would promote its endocytosis (By similarity).
    SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB5580-50UL,Anti-SCN8A Sodium Channel Antibody

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