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品种反应性 主要应用 宿主 格式 抗体类型 R, H IHC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB5466 Replaces 04-1050 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Synuclein γ Antibody 产品信息 格式 Serum 演示 Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue. 应用 应用 This Anti-Synuclein Antibody, γ is validated for use in WB, IH for the detection of Synuclein. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western blot: 1:500-1:1,000.
Immunohistochemistry: 1:1,000 on frozen tissue.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Peptide corresponding to the amino acids 114-127 of human gamma synuclein protein. 宿主 Rabbit 特异性 Gamma synuclein. The immunizing peptide was chosen to reduce cross-reactivity of AB6466 with a and b-synuclein. Immunohistochemical and Western blot analysis of human brain indicates a high level of specificity. 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003087.1
Entrez基因汇总 Synuclein-gamma is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development. 基因符号 - PRSN
- SNCG
- PERSYN
- persyn
- Persyn
- synoretin
- BCSG1
- Synoretin
- Gamma-synuclein
- SR
UniProt编号 - O76070
UniProt汇总 FUNCTION: SwissProt: O76070 # Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
SIZE: 127 amino acids; 13331 Da
SUBUNIT: May be a centrosome-associated protein.
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Centrosome. Spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
TISSUE SPECIFICITY: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
DISEASE: SwissProt: O76070 # Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions.
SIMILARITY: SwissProt: O76070 ## Belongs to the synuclein family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
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