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merck millipore,默克密理博,AB5208-200UL,Anti-Sodium Channel Antibody, Voltage Gated, Brain Type III
产品名称：Anti-Sodium Channel Antibody, Voltage Gated, Brain Type III
产品型号：AB5208-200UL
This Anti-Sodium Channel Antibody, Voltage Gated, Brain Type III is validated for use in IH, WB for the detection of Sodium Channel.
merck millipore,默克密理博,AB5208-200UL,Anti-Sodium Channel Antibody, Voltage Gated, Brain Type III
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5208-200UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Sodium Channel Antibody, Voltage Gated, Brain Type III Alternate Names - SCN3A
- Nav1.3
产品信息 格式 Affinity Purified 控制 - CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen. The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 0.75 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). 应用 应用 This Anti-Sodium Channel Antibody, Voltage Gated, Brain Type III is validated for use in IH, WB for the detection of Sodium Channel. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 All procedures that are going to receive a full-length protein should be performed at 4°C, and the following protease inhibitor mixture should be used: pepstatin A (1 μg/mL), leupeptin (1 μg/mL), aprotinin (1 μg/mL), Pefabloc SC (0.2 mM), benzamidine (0.1 mg/mL), and calpain inhibitors I and II (8 μg/mL each).
Western blot: 1:200 using ECL on newborn rat brain.
Immunohistochemistry on frozen sections.
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Purified peptide of alpha subunit (amino acids 511-524) of rat Nav1.3
( type III voltage-gated sodium channel VGSC) (Accession P08104).浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Nav1.3 (type III a subunit of VGSC, Scn3a). Does not cross react with any other sodium channel antigens tested so far. 品种反应性 RatMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006922.3
- NM_001081676.1
- NM_001081677.1
Entrez基因汇总 Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. 基因符号 - NAC3
- SCN3A
- Nav1.3
- KIAA1356
UniProt编号 - Q9NY46
UniProt汇总 FUNCTION: SwissProt: Q9NY46 # Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
SIZE: 2000 amino acids; 226294 Da
SUBUNIT: The sodium channel consists of a large polypeptide and 2- 3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
DOMAIN: SwissProt: Q9NY46 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
PTM: May be ubiquitinated by NEDD4L; which would promote its endocytosis.
SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 200 µL
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