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merck millipore,默克密理博,AB1955,Anti-VE-Cadherin Antibody, phospho-specific [Tyr658]
产品名称：Anti-VE-Cadherin Antibody, phospho-specific [Tyr658]
产品型号：AB1955
Anti-VE-Cadherin Antibody, phospho-specific [Tyr658] detects level of VE-Cadherin & has been published & validated for use in WB.
merck millipore,默克密理博,AB1955,Anti-VE-Cadherin Antibody, phospho-specific [Tyr658]
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB1955 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-VE-Cadherin Antibody, phospho-specific [Tyr658] 背景信息 VE-cadherin is an endothelial specific adhesion molecule that is essential for the maintenance of endothelial barrier function and angiogenesis. It is linked to the actin cytoskeleton through a number of adaptor proteins including alpha, beta, and gamma catenin. Cytoskeletal dynamics and phosphorylation regulate VE-cadherin mediated cellcell adhesion. The interaction between cytosolic c-terminal Src kinase, SH2 domain and phosphorylated tyrosine 658 site of VE-Cadherin regulates density dependent cell proliferation. Phosphorylation of tyrosine 658 has been shown to lead to uncoupling of p120-catenin from the cytoplasmic tail of VE-cadherin. This phosphorylation event is sufficient to maintain cells in a mesenchymal state during the cell invasion phase of angiogenesis. 产品信息 格式 Affinity Purified 演示 Antibody is purified from rabbit serum. It is cross-adsorbed to nonphospho-peptide corresponding to the site of phosphorylation then affinity purified using phosphorylated VEcadherin (Tyr658) peptide. Antibody is supplied in 100 µl phosphate-buffered saline (no Ca2+, no Mg2+), pH 7.3, 50% glycerol, containing 1 mg/ml BSA, and 0.05% sodium azide. 应用 应用 Anti-VE-Cadherin Antibody, phospho-specific [Tyr658] detects level of VE-Cadherin & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Phosphorylated VE-cadherin (Tyr658) synthetic peptide corresponding to human amino acid residues around tyrosine 658. The sequence is conserved in mouse, rat, porcine, bovine, canine, chicken and chimpanzee. 宿主 Rabbit 特异性 The antibody detects a 120 kDa protein of VE-cadherin. 品种反应性 Human Species Reactivity Note This sequence is 100% homologous in mouse, rat, chicken, chimpanzee, cow, dog and pig VE-cadherin. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001795.2
Entrez基因汇总 This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. 基因符号 - 7B4
- CDH5
- VE-cadherin
- CD144
修改 - Phosphorylation
UniProt编号 - P33151
UniProt汇总 FUNCTION: SwissProt: P33151 # Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.
SIZE: 784 amino acids; 87516 Da
SUBCELLULAR LOCATION: Cell junction. Cell membrane; Single-pass type I membrane protein (Probable). Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.
TISSUE SPECIFICITY: Endothelial tissues and brain.
SIMILARITY: SwissProt: P33151 ## Contains 5 cadherin domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C for up to one year or 2°-8°C for short term storage from date of receipt.
Avoid repeated freeze/thaw cycles.包装信息 数量 100 µL
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