merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5052,Anti-Glycine Receptor Antibody

  • merck millipore,默克密理博,AB5052,Anti-Glycine Receptor Antibody

    产品名称：Anti-Glycine Receptor Antibody
    产品型号：AB5052
    Anti-Glycine Receptor Antibody detects level of Glycine Receptor & has been published & validated for use in IP & WB.

    merck millipore,默克密理博,AB5052,Anti-Glycine Receptor Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5052,Anti-Glycine Receptor Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5052
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Glycine Receptor Antibody
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Lyophilized from ammonium bicarbonate (5mM) some residual salt may be present. Reconstitute with 100 μL of PBS. Contains no preservatives.
    应用
    应用 Anti-Glycine Receptor Antibody detects level of Glycine Receptor & has been published & validated for use in IP & WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1000 using ECL

    Immunoprecipitation: 1:10 following the protocol of Raymond et al., Nature (1993) 361:637-641.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Peptide from the amino terminus of the human alpha1 glycine receptor subunit conjugated to KLH.
    宿主 Rabbit
    特异性 Recognizes glycine receptor alpha1. Shows cross reactivity to glycine receptor alpha2. subunits The antibody has been used successfully in Western blot and immunoprecipitation assays with cell extracts containing recombinant human glycine receptors and with homogenates of mouse spinal cord. By Western blot the antibody recognizes a protein with a molecular weight of ~ 48 kD.
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000171.2
    Entrez基因汇总 The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha and beta subunits. The GLRB gene (MIM 138492) encodes the beta subunit of the receptor.[supplied by OMIM]
    基因符号
    • MGC138879
    • GLRA1
    • MGC138878
    • STHE
    UniProt编号
    • P23415
    UniProt汇总 FUNCTION: SwissProt: P23415 # The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
    SIZE: 457 amino acids; 52624 Da
    SUBUNIT: Pentamer composed of alpha and beta subunits.
    SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
    DISEASE: SwissProt: P23415 # Defects in GLRA1 are a cause of startle disease (STHE) [MIM:149400]; also known as hereditary hyperekplexia or congenital stiff-person syndrome. STHE is a genetically heterogeneous neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Inheritance can be autosomal dominant or recessive.
    SIMILARITY: SwissProt: P23415 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
    MISCELLANEOUS: The alpha subunit binds strychnine.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,AB5052,Anti-Glycine Receptor Antibody

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