merck millipore,默克密理愽
  • merck millipore,默克密理博,AB3796,Anti-5'-Lipoxygenase Antibody

  • merck millipore,默克密理博,AB3796,Anti-5'-Lipoxygenase Antibody

    产品名称：Anti-5'-Lipoxygenase Antibody
    产品型号：AB3796
    Anti-5'-Lipoxygenase Antibody detects level of 5'-Lipoxygenase & has been published & validated for use in ELISA, IP & WB.

    merck millipore,默克密理博,AB3796,Anti-5'-Lipoxygenase Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB3796,Anti-5'-Lipoxygenase Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rb, H, M, RWB, ELISARbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3796
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-5'-Lipoxygenase Antibody
    Alternate Names
    • 5-LO
    • Arachidonate 5-lipoxygenase
    背景信息 5'-Lipoxygenase is a critical enzyme in the formation of leukotrienes from arachidonic acid. Upon activation, the enzyme translocates to either a nuclear or plasma membrane compartment.
    产品信息
    格式 Purified
    控制
    • POSITIVE CONTROL: placenta, lung, and leukocytes.
    演示 Purified immunoglobulin in PBS with 50% Glycerol and 0.02% sodium azide
    应用
    应用 Anti-5'-Lipoxygenase Antibody detects level of 5'-Lipoxygenase & has been published & validated for use in ELISA, IP & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1:1,000. Reacts with a 79 kDa band
    Immunoprecipitation: 5 μL/mL lysate
    ELISA: 1:1000 – 1:100,000
    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Purified human 5'-Lipoxygenase
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 5'-Lipoxygenase
    品种反应性 RabbitHumanMouseRat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000698.2
    Entrez基因汇总 This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
    基因符号
    • EC 1.13.11.34
    • ALOX5
    • 5-lipoxygenase
    • 5LPG
    • MGC163204
    • LOG5
    • 5-LO
    UniProt编号
    • P09917
    UniProt汇总 COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 2 calcium ions per subunit (By similarity).
    SIZE: 674 amino acids; 77983 Da
    SUBCELLULAR LOCATION: Cytoplasm; Peripheral membrane protein. Note=Calcium binding promotes binding to membranes.
    PTM: Serine phosphorylation of LOX5 by MAPKAPK2 is stimulated by arachidonic acid. Serine phosphorylation of LOX5 on Ser-523 by PKA has an inhibitory effect.
    SIMILARITY: SwissProt: P09917 ## Belongs to the lipoxygenase family. & Contains 1 PLAT domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB3796,Anti-5'-Lipoxygenase Antibody

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