merck millipore,默克密理愽
  • merck millipore,默克密理博,AB3629,Anti-Caspase 9 Antibody, active (cleaved) form

  • merck millipore,默克密理博,AB3629,Anti-Caspase 9 Antibody, active (cleaved) form

    产品名称：Anti-Caspase 9 Antibody, active (cleaved) form
    产品型号：AB3629
    Anti-Caspase 9 Antibody, active (cleaved) form detects level of Caspase 9 & has been published & validated for use in IP, WB & IC.

    merck millipore,默克密理博,AB3629,Anti-Caspase 9 Antibody, active (cleaved) form

  • 产品介绍
  • merck millipore,默克密理博,AB3629,Anti-Caspase 9 Antibody, active (cleaved) form

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3629
    Replaces 04-443
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Caspase 9 Antibody, active (cleaved) form
    背景信息 Caspase-9 is an important member of the caspase family. When cytochrome c is released from the mitochondria early upon apoptosis induction, it associates with Apaf-1 and procaspase-9 and forms an apoptosome. This complex cleaves procaspase-9 into a large 37kDa subunit and a small 10kDa subunit.
    产品信息
    格式 Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS, containing 50% glycerol, 0.5% BSA and 0.02% thimerosal.
    应用
    应用 Anti-Caspase 9 Antibody, active (cleaved) form detects level of Caspase 9 & has been published & validated for use in IP, WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Western blot: 0.5-4 μg/mL

    Immunoprecipitation: 10-20 μg/mL

    Immunocytochemistry: 10-20 μg/mL

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide. FQEGLRTFDQLD
    表位 active (cleaved) form
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 AB3629 detects only the cleaved large 37kDa subunit and does not detect the precursor form in cells undergoing apoptosis. It also does not detect other caspases.
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_032996.1
    • NM_001229.2
    Entrez基因汇总 This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms.
    基因符号
    • Caspase-9 subunit p10].
    • CASP9
    • CASP-9
    • ICE-LAP6
    • APAF3
    • MCH6
    • CASPASE-9c
    • OTTHUMP00000044594
    • APAF-3
    • EC 3.4.22.62 [Contains: Caspase-9 subunit p35
    UniProt编号
    • P55211
    UniProt汇总 FUNCTION: SwissProt: P55211 # Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
    SIZE: 416 amino acids; 46281 Da
    SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts with the inhibitors BIRC2, BIRC4, BIRC5 and BIRC7.
    TISSUE SPECIFICITY: Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues.
    PTM: Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase- 3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
    SIMILARITY: SwissProt: P55211 ## Belongs to the peptidase C14 family. & Contains 1 CARD domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C. For optimal storage, aliquot and freeze at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB3629,Anti-Caspase 9 Antibody, active (cleaved) form

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