merck millipore,默克密理愽
  • merck millipore,默克密理博,AB3244,Anti-GLP-1 (7-36) Antibody, CT amide-reactive

  • merck millipore,默克密理博,AB3244,Anti-GLP-1 (7-36) Antibody, CT amide-reactive

    产品名称：Anti-GLP-1 (7-36) Antibody, CT amide-reactive
    产品型号：AB3244
    Anti-GLP-1 (7-36) Antibody, C-terminus amide-reactive detects level of GLP-1 (7-36) & has been published & validated for use in ELISA, RIA.

    merck millipore,默克密理博,AB3244,Anti-GLP-1 (7-36) Antibody, CT amide-reactive

  • 产品介绍
  • merck millipore,默克密理博,AB3244,Anti-GLP-1 (7-36) Antibody, CT amide-reactive

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MaELISARbSerumPolyclonal Antibody
    描述
    产品目录编号 AB3244
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-GLP-1 (7-36) Antibody, CT amide-reactive
    Alternate Names
    • Glucagon-like peptide-1
    产品信息
    格式 Serum
    演示 Rabbit serum, diluted. Liquid in PBS containing 0.05% sodium azide.
    应用
    应用 Anti-GLP-1 (7-36) Antibody, C-terminus amide-reactive detects level of GLP-1 (7-36) & has been published & validated for use in ELISA, RIA.
    主要应用
    • ELISA
    应用说明 RIA: 1:300,000. Ka = 0.8 x 10E12 l/mol for GLP-1(7-36) amide. Detection limit 0.1 fmol/tube, 95% confidence limits.

    EIA (capture). Detection limit 1.5 pmol/liter.

    Note: Plasma samples require extraction for RIA, but not for sandwich EIA. Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Whole synthetic peptide.
    表位 C-terminus amide-reactive
    宿主 Rabbit
    特异性 Glucagon-like peptide-1(7-36) amide (GLP-1), C-terminal reactive. Cross-reacts fully with GLP-1(1-36) amide but shows <0.1% cross reactivity with the unamidated forms GLP-1(7-37) and GLP-1(1-37) or other related peptides such as hGLP-2, glucagon, hGIP and VIP.

    SPECIES REACTIVITIES: Most mammalian species. GLP-1 is identical in all mammalian species studied except guinea pig and presumably its South American rodent relatives.
    品种反应性 Mammals
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002054.2
    Entrez基因汇总 The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
    基因符号
    • GLP2
    • GCG
    • GLP1
    • glucagon
    • GRPP
    非反应性品种
    • Guinea Pig
    UniProt编号
    • P01275
    UniProt汇总 FUNCTION: SwissProt: P01275 # Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
    SIZE: 180 amino acids; 20909 Da
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
    PTM: Proglucagon is post-translationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
    SIMILARITY: SwissProt: P01275 ## Belongs to the glucagon family.
    MISCELLANEOUS: In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB3244,Anti-GLP-1 (7-36) Antibody, CT amide-reactive

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