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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Gp Serum Polyclonal Antibody 描述 产品目录编号 AB2204 描述 Anti-BMAL1 Antibody Alternate Names - basic-helix-loop-helix-PAS orphan MOP3 2 <br />member of PAS superfamily 3
- ARNT-like protein 1, brain and muscle
- Basic-helix-loop-helix-PAS protein MOP3
- Brain and muscle ARNT-like 1
- Member of PAS protein 3
- aryl hydrocarbon receptor nuclear translocator-like
- bHLH-PAS protein JAP3
- bHLH-PAS protein JAP3
背景信息 Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock. 产品信息 格式 Serum 控制 - C2C12 Tissue lysate
演示 Serum with 0.05% NaN3 应用 应用 Anti-BMAL1 Antibody is an antibody against BMAL1 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Recombinant Protein 表位 C-Terminus 宿主 Guinea Pig 特异性 Cat. # AB2204 will recognize the C-terminus of BMAL1. 品种反应性 RatHumanMouse Species Reactivity Note Mouse, Human and Rat. Reactivity with other species has not been tested. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_031515
基因符号 - TIC
- BMAL1
- BMAL1c
- JAP3
- MGC47515
- MOP3
- PASD3
UniProt编号 - O00327
UniProt汇总 FUNCTION: ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity).
SUBUNIT: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo.
SUBCELLULAR LOCATION: Nucleus (By similarity).
ALTERNATIVE PRODUCTS: 8 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist.产品使用声明 质量保证 Routinely tested on C2C12 tissue lysate
Lot Specific Tested Application 1: Western Blot
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. 包装信息 数量 50 µL
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