merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1919,Anti-Integrin α4 Antibody, PhosphoSerine 988

  • merck millipore,默克密理博,AB1919,Anti-Integrin α4 Antibody, PhosphoSerine 988

    产品名称：Anti-Integrin α4 Antibody, PhosphoSerine 988
    产品型号：AB1919
    This Anti-Integrin α4 Antibody, PhosphoSerine 988 is validated for use in ELISA, IP, WB for the detection of Integrin α4.

    merck millipore,默克密理博,AB1919,Anti-Integrin α4 Antibody, PhosphoSerine 988

  • 产品介绍
  • merck millipore,默克密理博,AB1919,Anti-Integrin α4 Antibody, PhosphoSerine 988

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISARbSerumPolyclonal Antibody
    描述
    产品目录编号 AB1919
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin α4 Antibody, PhosphoSerine 988
    Alternate Names
    • VLA-4
    • CD49d
    背景信息 Integrin alpha4 has been implicated in the pathogenesis of diseases such as asthma, arthritis, and multiple sclerosis. Phosphorylation of the cytosolic tail of integrin alpha4 at position 988 is required for optimal alpha4beta1 integrin-mediated directed cell migration. In the absence of phosphorylation at Ser988, the cytosolic tail of integrin alpha4 binds tightly to the signaling adaptor protein, paxillin, inhibiting cell migration. Phosphorylation of alpha4 at Ser988 promotes dissociation from paxillin thereby enhancing cell migration (Han, 2003). MW is approximately 150 kDa.
    产品信息
    格式 Serum
    控制
    • POSITIVE CONTROL: Jurkat cells
    演示 Liquid rabbit serum containing no preservative.
    应用
    应用 This Anti-Integrin α4 Antibody, PhosphoSerine 988 is validated for use in ELISA, IP, WB for the detection of Integrin α4.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 ELISA: 1:10,000 (direct)

    Western blot: 1:1,000 to 1:5,000. On western blots of Jurkat cell extracts the antibody recognizes a major band at 140 kDa corresponding to Integrin alpha4 as well as 3 weak bands at approximately 60 kDa that are believed to be non-specific.

    Immunoprecipitation: 5 μL per 500 μg whole Jurkat cell lysate.

    NOTE: the use of specific inhibitors of phosphoserine phosphatse activity such as okadaic acid or NaF is strongly recommended during the preparation of protein extracts for western blot and immunoprecipitation.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to the cytoplasmic tail of human integrin alpha4 (a.a. 986-995) containing a phosphorylated serine at position 988. The phosphopeptide was conjugated to KLH using gluteraldehyde.
    表位 PhosphoSerine 988
    宿主 Rabbit
    特异性 Integrin alpha4 phosphorylated on serine 988. Does not react with integrin alpha4 that is not phosphorylated at serine 988 (Han, 2001).
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000885.4
    Entrez基因汇总 The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
    基因符号
    • CD49d
    • ITGA4
    • MGC90518
    • VLA-4
    • IA4
    • CD49D
    修改
    • Phosphorylation
    UniProt编号
    • P13612
    UniProt汇总 FUNCTION: SwissProt: P13612 # Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
    SIZE: 1038 amino acids; 115333 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DOMAIN: SwissProt: P13612 The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
    PTM: Phosphorylation on Ser-1027 inhibits PXN binding.
    SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB1919,Anti-Integrin α4 Antibody, PhosphoSerine 988

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