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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB1726 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Connexin 40 Antibody Alternate Names - CxA-5
- Cx40
- Gap Junction alpha-5 Protein
背景信息 Mouse Connexin 40 is a 358 amino acid gap junction protein with a predicted M.W. of ~40 kDa. It is prominently expressed in lung, heart and skin (see reviews: Kumar & Giula 1996; White, 1995; Evans, 1994; Beyer , 1990; Henneman, 1992; Traub, 1994; Goliger & Paul 1994). One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. 产品信息 格式 Affinity Purified 控制 - Placenta lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 15 mM NaCl containing 0.05% sodium azide. 应用 应用 Anti-Connexin 40 Antibody is an antibody against Cx40 for use in IHC & WB. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: An 1:50 dilution of a representative lot detected Connexin 40 immunoreactivity associated with the gap junction between the cardiac myoepithial cells in mouse heart tissue sections.
Western Blot Analysis: An 1:1000 dilution of a representative lot detected Connexin 40 in human (HEK293, HeLa, HepG2, HUVEC, Jurkat) and murine (C2C12, HIN/3T3) cell lysates.
Western Blot Analysis: An 1:000 dilution of a representative lot detected Connexin 40 in human, mouse, and rat heart tissue homogenates, as well as in mouse brain tissue homogenates.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Anti-Connexin 40 is made against a 19 amino acid peptide sequence within the C-terminal cytoplasmic domain of mouse C×40 (2). Peptide sequence is conserved in human and rat Cx40 (100%), chicken Cx42 (77%), human Cx50 (87%), rat Cx50 (81%) and sheep Cx49 (87%). 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Reacts with mouse connexin 40. 品种反应性 RatHumanMouse Species Reactivity Note Human, mouse, and rat. Reactivity with other species has not been determined. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005257
Entrez基因汇总 This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq] 基因符号 - Cx40
- GJA5
- CX40
- Connexin-40
- MGC11185
纯化方法 Immunoaffinity purified UniProt编号 - P36382
UniProt汇总 FUNCTION: SwissProt: P36382 # One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
SIZE: 358 amino acids; 40380 Da
SUBUNIT: A connexon is composed of a hexamer of connexins.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
DISEASE: SwissProt: P36382 # Defects in GJA5 are the cause of atrial fibrillation type 4 (ATFB4) [MIM:108770]; also known as atrial standstill. ATFB is characterized by rapid and irregular activation of the atrium.
SIMILARITY: SwissProt: P36382 ## Belongs to the connexin family. Alpha-type (group II) subfamily产品使用声明 质量保证 Evaluated by Western Blot on Jurkat lysates.
Western Blot Analysis: A 1:1000 dilution of this lot detected Connexin 40 in 10 μg of Jurkat lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 50 µg
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