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merck millipore,默克密理博,676501,VEGFR Tyrosine Kinase Inhibitor V - Calbiochem
产品名称：VEGFR Tyrosine Kinase Inhibitor V - Calbiochem
产品型号：676501
The VEGFR Tyrosine Kinase Inhibitor V controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,676501,VEGFR Tyrosine Kinase Inhibitor V - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₅H₂₂N₂O₄ • HCl • H₂O 描述 概述 A cell-permeable, ATP-binding pocket-targeting N-cyclopropylnaphthamide compound that acts as a potent inhibitor against VEGFR1/2/3 (IC50 = 0.6 nM against VEGFR2), c-FMS, RET, Lyn, and c-KIt, while exhibiting much reduced activity against 36 other commonly studied kinases. Selectively inhibits HUVEC proliferation induced by VEGF over bFGF (IC50 = 0.91 vs. 170 nM, respectively). It is orally active in mice and rats and is shown to effectively reduce VEGF-mediated vascular permeability and angiogenesis in vivo. 产品目录编号 676501 品牌系列 Calbiochem®
同义词 N-Cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide, HCl, VEGF Receptor Tyrosine Kinase Inhibitor V, VEGFR2 Kinase Inhibitor XXIII, VEGFR1 Kinase Inhibitor VI, VEGFR3 Kinase Inhibitor VI 参考 参考 Harmange, J.C., et al. 2008. J. Med. Chem. 51, 1649.
Weiss, M.M., et al. 2008. J. Med. Chem. 51, 1668.产品信息 形式 Beige solid Hill配方 C₂₅H₂₂N₂O₄ • HCl • H₂O 化学配方 C₂₅H₂₂N₂O₄ • HCl • H₂O Molar Mass 468.9 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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