merck millipore,默克密理博,662105,Ubiquitin E1 Inhibitor, PYR-41

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Merck Millipore 默克密理愽

merck millipore,默克密理博,662105,Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem

经验配方
C₁₇H₁₃N₃O₇ • 3H₂O

描述
概述	A cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC₅₀ <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
产品目录编号	662105
品牌系列	Calbiochem®
同义词	4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41

参考
参考	Yang, Y., et al. 2007. Cancer Res. 67, 9472.

生物信息
纯度	≥90% by HPLC (sum of two isomers)

理化信息
溶解度	DMSO

安全信息
R相	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S相	S: 22-24/25-36-45 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Irritant
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,662105,Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem

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