merck millipore,默克密理博,04-435,Anti-Bcl-10 Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-435,Anti-Bcl-10 Antibody, rabbit monoclonal
产品名称：Anti-Bcl-10 Antibody, rabbit monoclonal
产品型号：04-435
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Bcl-10 Antibody, Rabbit is an antibody against More>>

merck millipore,默克密理博,04-435,Anti-Bcl-10 Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-435,Anti-Bcl-10 Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Human Only	WB, FC	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-435
Replaces	04-1101
品牌系列	Upstate
商名	Upstate
描述	Anti-Bcl-10 Antibody, rabbit monoclonal

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Bcl-10 Antibody, Rabbit is an antibody against Bcl-10 for use in FC, IP, WB, IH(P).
主要应用	Western Blotting Flow Cytometry

生物信息
免疫原品种	KLH-conjugated synthetic peptide corresponding to the N-terminal region of human Bcl-10.
宿主	Rabbit
特异性	Recognizes a region near the N-terminus domain of human Bcl-10.
同种型	IgG
品种反应性	Human Only
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_003921.3
Entrez基因汇总	This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
基因符号	hCLAP BCL10 mE10 CARMEN cCARMEN Bcl-10 Cellular-E10 CLAP CIPER c-E10
UniProt编号	O95999
UniProt汇总	FUNCTION: SwissProt: O95999 # Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. SIZE: 233 amino acids; 26252 Da SUBUNIT: Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C- terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. TISSUE SPECIFICITY: Ubiquitous. PTM: Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. DISEASE: SwissProt: O95999 # A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. & Defects in BCL10 are involved in various types of cancer. SIMILARITY: SwissProt: O95999 ## Contains 1 CARD domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.