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经验配方 CAS号 C₂₆H₂₈N₆ 16858-02-9 描述 概述 Lipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca2+ levels in cells. Also useful in extracting Aβ amyloid deposits from Alzheimer’s disease brain tissue. Has extremely high affinity for heavy metals but low affinity for Ca2+ and Mg2+. Induces DNA fragmentation when chelated with Zn2+ and induces apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2 (Cat. No. 551826). 产品目录编号 616394 品牌系列 Calbiochem®
同义词 N,N,Nʹ,Nʹ-tetrakis-(2-Pyridylmethyl)ethylenediamine 参考 参考 Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209.
Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223.
Aballay, A., et al. 1995. Biochem. J. 312, 919.
Jiang, S., et al. 1995. Lab. Invest. 73, 111.
Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539.
McCabe, M.J., et al. 1993. Lab. Invest. 69, 101.
Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553.
Baba, A., et al. 1991. Brain Res. 557, 103.
Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224.
Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593.
Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345.
Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.产品信息 CAS号 16858-02-9 形式 Tan solid Hill配方 C₂₆H₂₈N₆ 化学配方 C₂₆H₂₈N₆ Molar Mass 424.6 结构配方图像 生物信息 纯度 ≥97% by titration 理化信息 溶解度 DMSO or EtOH, or PBS 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +15°C to +30°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Alternately, acidify (pH ≤3) with HCl for long term storage. Stock solutions are stable for up to 3 months at -20°C.
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