merck millipore,默克密理愽
  • merck millipore,默克密理博,575305,T0070907 - CAS 313516-66-4 - Calbiochem

  • merck millipore,默克密理博,575305,T0070907 - CAS 313516-66-4 - Calbiochem

    产品名称：T0070907 - CAS 313516-66-4 - Calbiochem
    产品型号：575305
    A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM.

    merck millipore,默克密理博,575305,T0070907 - CAS 313516-66-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,575305,T0070907 - CAS 313516-66-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₂H₈ClN₃O₃313516-66-4
    描述
    概述 A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.
    产品目录编号 575305
    品牌系列 Calbiochem®
    同义词 2-Chloro-5-nitro-N-(4-pyridyl)benzamide
    参考
    参考 Lee, G., et al. 2002. J. Biol. Chem. 277, 19649.
    产品信息
    CAS号 313516-66-4
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₁₂H₈ClN₃O₃
    化学配方 C₁₂H₈ClN₃O₃
    Molar Mass 277.7
    可逆 N
    结构配方图像
    生物信息
    主靶 PPARγ
    主靶Ki 1 nM for PPARγ
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,575305,T0070907 - CAS 313516-66-4 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,582243,Tetanus Toxin, Clostridium tetani - Calbiochem


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