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merck millipore,默克密理博,559404,SB 239063 - CAS 798558-40-4 - Calbiochem
产品名称：SB 239063 - CAS 798558-40-4 - Calbiochem
产品型号：559404
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the α- and β-isoforms (IC₅₀ = 44 nM), but not the γ- or δ-isoform (IC₅₀ > 100 µM), of MAP kinase p38.
merck millipore,默克密理博,559404,SB 239063 - CAS 798558-40-4 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₂₁FN₄O₂ 798558-40-4 描述 概述 A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the α- and β-isoforms (IC50 = 44 nM), but not the γ- or δ-isoform (IC50 > 100 µM), of MAP kinase p38. It inhibits IL-1 and TNF-α production (IC50 = 120 nM and 350 nM, respectively) in LPS-stimulated human peripheral blood monocytes. Also reduces brain injury and neurological deficits in cerebral focal ischemia and reduces myocardial reperfusion injury by reducing the expression of endothelial adhesion molecule and by blocking polymorphonuclear (PMN) leukocytes accumulation. 产品目录编号 559404 品牌系列 Calbiochem®
同义词 trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)imidazole, p38 MAP Kinase Inhibitor XV 参考 参考 Gao, F., et al. 2002. Cardiovasc. Res. 53, 414.
Ju, H., et al. 2002. J. Pharmacol. Exp. Ther. 301, 15.
Legos, J.J., et al. 2002. Eur. J. Pharmacol. 447, 37.
Barone, F.C., et al. 2001. J. Pharmacol. Exp. Ther. 296, 312.
Ward, K.W., et al. 2001. Pharm. Res. 18, 1336.
Underwood, D.C., et al. 2000. J. Pharmacol. Exp. Ther. 293, 281.
Underwood, D.C., et al. 2000. Am. J. Physiol. Lung Cell Mol. Physiol. 279, L895.产品信息 CAS号 798558-40-4 具有ATP竞争性 Y 形式 White solid Hill配方 C₂₀H₂₁FN₄O₂ 化学配方 C₂₀H₂₁FN₄O₂ Molar Mass 368.4 可逆 Y 结构配方图像 生物信息 主靶 MAPKp38α & β 主靶IC50 44 nM against of the α- and β-isoforms of MAP kinase p38; < 100 µM against the γ- or δ-isoform of MAP kinase p38 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 Warm DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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