merck millipore,默克密理愽
  • merck millipore,默克密理博,559273,S6K1 Inhibitor, PF-4708671 - Calbiochem

  • merck millipore,默克密理博,559273,S6K1 Inhibitor, PF-4708671 - Calbiochem

    产品名称：S6K1 Inhibitor, PF-4708671 - Calbiochem
    产品型号：559273
    The S6K1 Inhibitor, PF-4708671 controls the biological activity of S6K1. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,559273,S6K1 Inhibitor, PF-4708671 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,559273,S6K1 Inhibitor, PF-4708671 - Calbiochem

    重要规格表

    经验配方
    C₁₉H₂₁F₃N₆
    描述
    概述 A cell-permeable piperazinyl-pyrimidine compound that acts as an inhibitor against S6K1 (Ki = 20 nM; IC50 = 160 nM) and MSK1 (IC50 = 950 nM) kinase activity, exhibiting little or much reduced potency against 85 other protein and lipid kinases (IC50 = 4.7, 9.2, 65 µM, respectively, against RSK1, RSK2, and S6K2; ≤27% inhibition of the rest at 1 µM). Shown to selectively inhibit IGF1- and PMA-stimulated S6K1 substrates phosphorylation in HEK-293 cells in a dose-dependent manner (up to 10 µM) in vitro and alleviate heart remodeling and functional damage in a MI (myocardial infarction) model in mice in vivo (75/mg/kg/daily i.p.).
    产品目录编号 559273
    品牌系列 Calbiochem®
    同义词 (2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole, p70 Ribosomal S6 Kinase 1 Inhibitor
    参考
    参考 Di, R., et al. 2012. Biochem. J. 441, 199.
    Pearce, L.R., et al. 2010. Biochem. J. 431, 245.
    产品信息
    形式 Off-white solid
    Hill配方 C₁₉H₂₁F₃N₆
    化学配方 C₁₉H₂₁F₃N₆
    Molar Mass 390.4
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C.) Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,559273,S6K1 Inhibitor, PF-4708671 - Calbiochem

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