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merck millipore,默克密理博,554328,Resveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem
产品名称：Resveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem
产品型号：554328
A cell-permeable triacetate resveratrol prodrug that is easily converted to resveratrol by esterase activity and exhibits similar bioactivity as resveratrol in cell cultures.
merck millipore,默克密理博,554328,Resveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₁₈O₈ 42206-94-0 描述 概述 A cell-permeable triacetate resveratrol (Cat. No. 554325) prodrug that is easily converted to resveratrol by esterase activity and exhibits similar bioactivity as resveratrol in cell cultures. Cremophor EL is reported to protect the prodrug from fast hydrolysis and resveratrol conversion in mouse serum at 37°C (100% conversion within 20 sec vs. >300 min or T1/2 of 48 min delivered with DMSO or 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O, respectively; [prodrug]t=0 = 100 µM), although the active drug resveratrol is stable for more than 27 h under the same condition without Cremophor EL. When dosed at 10 mg/kg and delivered with 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O intraperitoneally before, but not after, exposure to lethal γ-irradiation (9.75 Gy), the prodrug, but not resveratrol, is shown to greatly prevent irradiation-induced death in mice in vivo (survival rate = 77.4% with 10 mg/kg prodrug vs. ≤28.3% with 10 mg/kg resveratrol, vehicle alone, or no pretreatment at all). 产品目录编号 554328 品牌系列 Calbiochem®
同义词 trans-3,5,4ʹ-Triacetylstilbene, 3,5,4ʹ-Tri-O-acetylresveratrol 参考 参考 Koide, K., et al. 2011. ACS Med. Chem. Lett. 2, 270.
Hsieh, T.C., et al. 2011. Int. J. Cancer 129, 2732.产品信息 CAS号 42206-94-0 形式 White powder Hill配方 C₂₀H₁₈O₈ 化学配方 C₂₀H₁₈O₈ Molar Mass 354.4 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,648468,TRITON X-114, PROTEIN GRADE Detergent, 10% Solution, Sterile-Filtered - CAS 9036-19-5 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,HTS123RTA,Ready-to-Assay™ BB1 Bombesin Receptor Frozen Cells
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