merck millipore,默克密理愽
  • merck millipore,默克密理博,540218,LYP Inhibitor II, LTV-1 - Calbiochem

  • merck millipore,默克密理博,540218,LYP Inhibitor II, LTV-1 - Calbiochem

    产品名称：LYP Inhibitor II, LTV-1 - Calbiochem
    产品型号：540218
    The LYP Inhibitor II, LTV-1 controls the biological activity of LYP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,540218,LYP Inhibitor II, LTV-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,540218,LYP Inhibitor II, LTV-1 - Calbiochem

    重要规格表

    经验配方
    C₂₆H₂₀N₂O₅S
    描述
    概述 A cell-permeable thiobarbituryl-benzoate compound that acts as a highly potent and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50 = 508 nM) and thereby enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki = 384 nM). Also shown to inhibit the mutant, disease associated LYP-Trp620 activity. Binds to the phosphate-binding loop and mimicks the phosphotyrosine moiety of substrates. Displays acceptable selectivity over a wide range of protein phosphatases (TCPTP, PTP1B, PEP (mouse LYP), SHP1, CD45 and PTP-PEST: IC50 = 1.52, 1.59, 7.56, 23.2, 30.1, and 100 µM, respectively). Does not exhibit any toxicity at pharmacological doses when tested in primary human cell lines.
    产品目录编号 540218
    品牌系列 Calbiochem®
    同义词 (E)-3-((4-((4,6-Dioxo-2-thioxo-1-o-tolyltetrahydropyrimidin-5(6H)-ylidene)methyl)phenoxy)methyl)benzoic acid, Lymphoid Tyrosine Phosphatase Inhibitor II, LTV-1
    参考
    参考 Vang, T., et al. 2012. Nat. Chem. Biol. 8, 437.
    产品信息
    形式 Orange powder
    Hill配方 C₂₆H₂₀N₂O₅S
    Molar Mass 472.5
    可逆 Y
    结构配方图像
    生物信息
    主靶 LYP
    主靶IC50 508 nM for LYP
    副靶 Othet PTPases
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C>
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,540218,LYP Inhibitor II, LTV-1 - Calbiochem

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