merck millipore,默克密理愽
  • merck millipore,默克密理博,529578,PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem

  • merck millipore,默克密理博,529578,PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem

    产品名称：PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem
    产品型号：529578
    The PPM1D Phosphatase Inhibitor, also referenced under CAS 1087-07-6, controls the biological activity of PPM1D Phosphatase. This small molecule/inhibitor is primarily used for Phosphorylation & Depho More>>

    merck millipore,默克密理博,529578,PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,529578,PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₂OS₂1087-07-6
    描述
    概述 A cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC50 = 8.4 µM), while exhibiting little activity against PPM1A even at concentrations as high as 100 µM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF50 = 0.13, 0.17 & 0.48 µM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF50 = 34 & >50 µM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.
    产品目录编号 529578
    品牌系列 Calbiochem®
    同义词 2,5-bis-(2-Thienylidene)cyclopentanone, CCT007093, PP2Cδ Inhibitor I, Wip1 Inhibitor I
    参考
    参考 Rayter, S., et al. 2008. Oncogene 27, 1036.
    产品信息
    CAS号 1087-07-6
    形式 Yellow solid
    Hill配方 C₁₅H₁₂OS₂
    化学配方 C₁₅H₁₂OS₂
    Molar Mass 272.4
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,529578,PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem

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