merck millipore,默克密理愽
  • merck millipore,默克密理博,528111,PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem

  • merck millipore,默克密理博,528111,PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem

    产品名称：PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem
    产品型号：528111
    The PI 3-Kα Inhibitor IV, also referenced under CAS 1188890-32-5, controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation a More>>

    merck millipore,默克密理博,528111,PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,528111,PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₅N₃O₂S • 2HCl1188890-32-5
    描述
    概述 A cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-kinases (IC50 = 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively) and inhibits non-PI 3-K kinases only at much higher concentrations (IC50 ≥3.4 µM for Cdk2/E, KDR, PKA, and PKCα). Shown to inhibit cell proliferation (IC50 = 580 nM) and serum-stimulated Akt phosphorylation (IC50 <3 µM) in A375 melanoma cells.
    产品目录编号 528111
    品牌系列 Calbiochem®
    同义词 3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol, 2HCl, PI 3-K Inhibitor IV
    参考
    参考 Hayakawa, M., et al. 2006. Bioorg. Med. Chem. 14, 6847.
    产品信息
    CAS号 1188890-32-5
    具有ATP竞争性 N
    形式 Off-white solid
    Hill配方 C₁₆H₁₅N₃O₂S • 2HCl
    化学配方 C₁₆H₁₅N₃O₂S • 2HCl
    Molar Mass 386.3
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 PI 3-Kα
    主靶IC50 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,528111,PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem

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