merck millipore,默克密理博,521232,PDGFR Tyrosine Kinase Inhibitor III - CAS 205254-94-0

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Merck Millipore 默克密理愽

merck millipore,默克密理博,521232,PDGFR Tyrosine Kinase Inhibitor III - CAS 205254-94-0 - Calbiochem
产品名称：PDGFR Tyrosine Kinase Inhibitor III - CAS 205254-94-0 - Calbiochem
产品型号：521232

merck millipore,默克密理博,521232,PDGFR Tyrosine Kinase Inhibitor III - CAS 205254-94-0 - Calbiochem

merck millipore,默克密理博,521232,PDGFR Tyrosine Kinase Inhibitor III - CAS 205254-94-0 - Calbiochem

经验配方	CAS号
C₂₇H₂₇N₅O₄	205254-94-0

描述
概述	A cell-permeable piperazinyl-quinazoline carboxamide compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of PDGF receptor family of tyrosine kinases (IC₅₀ = 0.05 µM for α-PDGFR; 0.08 µM for β-PDGFR; 0.05 µM for c-Kit; 0.23 µM for Flt3). Affects the activities of other kinases only at much higher concentrations (IC₅₀ ≥ 30 µM for EGFR, FGFR, Src, PKA & PKC). Reported to block the PDGF-BB induced proliferation of porcine aorta smooth muscle cells (IC₅₀ = 0.25 µM).
产品目录编号	521232
品牌系列	Calbiochem®
同义词	4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-phenoxyphenyl)-1-piperazinecarboxamide

参考
参考	Matsuno, K., et al. 2003. J. Med. Chem. 46, 4910. Matsuno, K., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3001. Matsuno, K., et al. 2002. J. Med. Chem. 45, 4513. Matsuno, K., et al. 2002. J. Med. Chem. 45, 3057.

生物信息
主靶	α-PDGFR
主靶IC₅₀	0.05 µM for α-PDGFR; 0.08 µM for β-PDGFR; 0.05 µM for c-Kit; 0.23 µM for Flt3
纯度	≥97% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Carcinogenic / Teratogenic
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

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