merck millipore,默克密理愽
  • merck millipore,默克密理博,506154,Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem

  • merck millipore,默克密理博,506154,Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem

    产品名称：Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem
    产品型号：506154
    A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α.

    merck millipore,默克密理博,506154,Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,506154,Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₃N₃O₂S60477-38-5
    描述
    概述 A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-α, p-Nitro (Cat. No. 506152).
    产品目录编号 506154
    品牌系列 Calbiochem®
    同义词 2-(4-Nitrophenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole
    参考
    参考 Pietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645.
    产品信息
    CAS号 60477-38-5
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₁₅H₁₃N₃O₂S
    化学配方 C₁₅H₁₃N₃O₂S
    Molar Mass 299.4
    可逆 N
    结构配方图像
    生物信息
    主靶 p53
    主靶IC50 ED50 = 30 nM in protecting etoposide-induced cortical neuron death
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,506154,Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem

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