- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,476495,PKD Inhibitor, CID755673 - CAS 521937-07-5 - Calbiochem
产品名称：PKD Inhibitor, CID755673 - CAS 521937-07-5 - Calbiochem
产品型号：476495
The PKD Inhibitor, CID755673, also referenced under CAS 521937-07-5, controls the biological activity of PKD. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation ap More>>
merck millipore,默克密理博,476495,PKD Inhibitor, CID755673 - CAS 521937-07-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₂H₁₁NO₃ 521937-07-5 描述 概述 A cell-permeable benzoxoloazepinolone compound that effectively inhibits syntide-2 (Cat. No. 05-23-4910) phosphorylation by all three PKD/PKCµ isoforms 1, 2, & 3 (IC50 = 182, 280, and 227 nM, respectively), while exhibiting ≥30-fold less potency towards Cdk activating kinase, Plk1, CaMKIIα, as well as 44 other kinases, 33 of which are not significantly inhibited even at concentrations as high as 10 µM, including Akt1/2 and PKCα/β/δ/ζ. Shown to block PMA- (Cat. No. 524400) induced PKD1 phosphorylation on Ser742 and Ser916 in LNCaP cells, PMA-induced HCAS5 nuclear export in HeLa cells, as well as other PKD-mediated cellular responses. The mode of inhibition is demonstrated not to be ATP-competitive in nature. Also reported to inhibit MAPKAPK2, GSK-3β, CKIδ, MK5 (PRAK), CDK2, and Erk1 kinase activity at much elevated concentrations (% inhibition by 10 µM inhibitor = 95, 86, 82, 75, 71, and 50, respectively). 产品目录编号 476495 品牌系列 Calbiochem®
同义词 7-Hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one, PKCμ Inhibitor 参考 参考 LaValle, C.R., et al. 2010. BMC Chemical Biology 10, 5.
Sharlow, E.R., et al. 2008. J. Biol. Chem. 283, 33516.产品信息 CAS号 521937-07-5 形式 Brown solid Hill配方 C₁₂H₁₁NO₃ 化学配方 C₁₂H₁₁NO₃ Molar Mass 217.2 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,14-586,MAPKAP Kinase 3 Protein, unactive, 50 µg
下一件merck millipore产品：merck millipore,默克密理博,MAB5428,Anti-Retinal Pigment Epithelium 65 Antibody
相关产品
merck millipore,默克密理博,493800,PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem
merck millipore,默克密理博,SF-1489,CCL5; Human, Cyanine 3 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,14-476,Cdk7/Cyclin H/MAT1 (CAK complex) Protein, active, 10 µg
merck millipore,默克密理博,MABN609,Anti-OCRL/INPP5b Antibody, clone N166A/26
merck millipore,默克密理博,14-586,MAPKAP Kinase 3 Protein, unactive, 50 µg
merck millipore,默克密理博,MAB5428,Anti-Retinal Pigment Epithelium 65 Antibody
merck millipore,默克密理博,ABE14,Anti-monomethyl Histone H3 Antibody (Arg26)
merck millipore,默克密理博,17-10226,LentiBrite ™ PSD95-RFP Lentiviral Biosensor
