merck millipore,默克密理愽
  • merck millipore,默克密理博,476300,Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem

  • merck millipore,默克密理博,476300,Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem

    产品名称：Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem
    产品型号：476300
    A potent immunosuppressant.

    merck millipore,默克密理博,476300,Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,476300,Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₃₉NO₆35891-70-4
    描述
    概述 A potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
    产品目录编号 476300
    品牌系列 Calbiochem®
    同义词 ISP-1, Thermozymocidin, [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid
    参考
    参考 Hanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
    Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
    Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
    Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
    Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
    Fujita, T., et al. 1994. J. Antibiot. 47, 208.
    产品信息
    CAS号 35891-70-4
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₂₁H₃₉NO₆
    化学配方 C₂₁H₃₉NO₆
    Molar Mass 401.5
    可逆 N
    结构配方图像
    生物信息
    主靶 Serine palmitoyltransferase
    主靶Ki 280 pM against serine palmitoyltransferase
    纯度 ≥95% by TLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO
    GHS安全信息
    RTECS JX3890000
    安全信息
    R相 R: 22

    Harmful if swallowed.
    S相 S: 36

    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,476300,Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem

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