merck millipore,默克密理愽
  • merck millipore,默克密理博,475990,mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem

  • merck millipore,默克密理博,475990,mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem

    产品名称：mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem
    产品型号：475990
    The mTOR Inhibitor IV, Ku-63794, also referenced under CAS 938440-64-3, controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylatio More>>

    merck millipore,默克密理博,475990,mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,475990,mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₅H₃₁N₅O₄938440-64-3
    描述
    概述 A cell-permeable pyrido-pyrimidine compound that acts as a highly selective and potent inhibitor against both mTORC1 & mTORC2 (IC50 = ~10 nM against mTOR activity in raptor or rictor immunoprecipitate from HEK293 with 100 µM ATP), with much reduced potency against MKK1 and PI 3-Kα (IC50 ~9 µM) and little or no activity toward more than 200 other protein and lipid kinases, including Akt, ATR, DNA-PK, PDK1, and PI 3-Kβ/γ/δ. Shown to effectively inhibit cellular mTOR phosphorylation on Ser2448/2481 as well as the phosphorylation and activation of mTORC1/2 downstream effector molecules such as Akt, S6K, 4E-BP1, but not RSK or Erk1/2, kinases that are not regulated by mTOR. Although Ku-63794 is shown not to affect IGF-1-induced Akt phosphorylation on Ser308 by PDK1 in mTORC2 knockout MEF cultures, Ku-63794 treatment of mTORC2-expressing MEF cells is shown to inhibit IGF-1-induced Akt Ser308 phosphorylation.
    产品目录编号 475990
    品牌系列 Calbiochem®
    同义词 rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol, Ku-0063794, mTOR Inhibitor IV, Ku-63794
    参考
    参考 Malagu, K., et al. 2009. Bioorg. Med. Chem. Lett. 19, 5950.
    Garcia-Martinez, J.M., et al. 2009. Biochem. J. 421, 29.
    产品信息
    CAS号 938440-64-3
    形式 Pale yellow solid
    Hill配方 C₂₅H₃₁N₅O₄
    化学配方 C₂₅H₃₁N₅O₄
    Molar Mass 465.5
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,475990,mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem

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