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merck millipore,默克密理博,474788,InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem
产品名称：InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem
产品型号：474788
Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex.
merck millipore,默克密理博,474788,InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₆H₄₁N₃O₅ 描述 概述 Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available. 产品目录编号 474788 品牌系列 Calbiochem®
同义词 Proteasome Inhibitor XI 应用数据 
参考 参考 Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
Wiertz, E.J., et al. 1996. Cell 84, 769.
Jensen, T.J., et al. 1995. Cell 83, 129.
Read, M.A., et al. 1995. Immunity 2, 493.
Rock, K.L., et al. 1994. Cell 78, 761.产品信息 形式 Liquid 配方 A 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH. Hill配方 C₂₆H₄₁N₃O₅ 化学配方 C₂₆H₄₁N₃O₅ Molar Mass 475.6 肽序列 Z-Leu-Leu-Leu-CHO 可逆 Y 生物信息 主靶Ki Ki = 4 nM for proteasomal inhibition 副靶 IKK 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 肽序列 Z-Leu-Leu-Leu-CHO 安全信息 R相 R: 11-22
Highly flammable.
Harmful if swallowed.S相 S: 16-7
Keep away from sources of ignition - No Smoking.
Keep container tightly closed.储存和货运信息 货运代码 Dry Ice Only
毒性 Flammable
有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 ≤ -70°C
避光 Protect from light
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initital thaw, aliquot and freeze (-70°C). 包装信息 惰性气体下包装 Packaged under inert gas
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