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merck millipore,默克密理博,171272,AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem
产品名称：AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem
产品型号：171272
The AMPK Activator VI, RSVA314 modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications.
merck millipore,默克密理博,171272,AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₈H₂₁N₃O₃ 316130-82-2 描述 概述 A cell permeable hydrozide that activates AMPK indirectly via a CaMKKβ-dependent pathway similar to resveratrol (Cat. No. 554325), which results in the phosphorylation of Thr-172 on the AMPKα2 subunit. This activator promotes lysosomal amyloid-β degradation in 3 cell lines nearly 40 times more potently than resveratrol with an IC50 of 1-2 µM. Treatment with RSVA314 at 1-3 µM results in a dose-dependent inhibition of the phosphorylation of 3 proteins downstream from mTOR activation including p70S6K, eukaryotic elongation factor 2 kinase (eEF2K), and S6 ribosomal protein, and promotes a robust increase in the phosphorylation of the protein raptor at Ser-792 in western blots. At the same concentrations, it elicits a strong, dose-dependent conversion of the light chain 3 (LC3) protein, a marker involved with autophagy induction, from LC3-I and LC3-II, also in western blots. 产品目录编号 171272 品牌系列 Calbiochem®
同义词 RSVA314, AMPK Signaling Activator VI 参考 参考 Vingtdeux, V., et al. 2011. FASEB J. 25, 219. 产品信息 CAS号 316130-82-2 形式 Yellow solid Hill配方 C₁₈H₂₁N₃O₃ 化学配方 C₁₈H₂₁N₃O₃ Molar Mass 327. 结构配方图像 生物信息 纯度 >90% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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