merck millipore,默克密理愽
  • merck millipore,默克密理博,420148,JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem

  • merck millipore,默克密理博,420148,JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem

    产品名称：JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem
    产品型号：420148
    The JAK3/GSK-3β/PKCα Inhibitor, also referenced under CAS 1260181-14-3, controls the biological activity of JAK3/GSK-3β/PKCα. This small molecule/inhibitor is primarily used for Phosphorylation & Deph More>>

    merck millipore,默克密理博,420148,JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420148,JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₇H₂₅F₃N₄O₄1260181-14-3
    描述
    概述 A cell-permeable phenyl-indolyl maleimide compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of GSK-3β, JAK3, PKCα and PKCθ (IC50 = 3, 8, 13 and 68 nM, respectively) with excellent selectivity over 40-kinases, including JAK1, JAK2 and Tyk2 (IC50 = 1.017, 2.55 and 8.055 µM, respectively). Shown to efficiently block interleukin stimulated STAT5 phosphorylation and T cell costimulation (IC50 = 0.525, 1.294 and 0.689 µM in IL15-MO7, IL2-CTLL and TCR/CD28-Jurkat cells, respectively).
    产品目录编号 420148
    品牌系列 Calbiochem®
    同义词 NIBR3049, 3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione, JAK3 Inhibitor XII
    参考
    参考 Haan, C., et al. 2011. Chem. Biol. 18, 314.
    Thoma, G., et al. 2011. J. Med. Chem. 54, 284.
    产品信息
    CAS号 1260181-14-3
    形式 Yellow solid
    Hill配方 C₂₇H₂₅F₃N₄O₄
    化学配方 C₂₇H₂₅F₃N₄O₄
    Molar Mass 526.5
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420148,JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem

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