merck millipore,默克密理愽
  • merck millipore,默克密理博,420126,JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem

  • merck millipore,默克密理博,420126,JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem

    产品名称：JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem
    产品型号：420126
    The JAK3 Inhibitor VI, also referenced under CAS 856436-16-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicat More>>

    merck millipore,默克密理博,420126,JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420126,JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₃N₃O • MeSO₃H856436-16-3
    描述
    概述 A cell-permeable 3′-pyridyl oxindole compound that acts as a potent and reversible inhibitor of JAK3 (IC50 = 27 nM)and displays ~16-fold greater selectivity over JAK2. Binds to the enzyme active site and prevents IL-2-induced cellular phosphorylation of JAK3 and STAT5. Inhibits IL-2-induced cell proliferation (IC50 = 760 and 250 nM for mouse CTLL and human T-cells, respectively) and alleviates oxazolone-induced ear odema in mouse with an efficacy comparable to that of Dexamethasone (Cat. No. 265005).
    产品目录编号 420126
    品牌系列 Calbiochem®
    参考
    参考 Chen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press.
    Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.
    产品信息
    CAS号 856436-16-3
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₁₈H₁₃N₃O • MeSO₃H
    化学配方 C₁₈H₁₃N₃O • MeSO₃H
    Molar Mass 383.4
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 JAK-3
    主靶IC50 27 nM
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420126,JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem

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