merck millipore,默克密理愽
  • merck millipore,默克密理博,412510,IRE1 Inhibitor I, STF-083010 - Calbiochem

  • merck millipore,默克密理博,412510,IRE1 Inhibitor I, STF-083010 - Calbiochem

    产品名称：IRE1 Inhibitor I, STF-083010 - Calbiochem
    产品型号：412510
    The IRE1 Inhibitor I, STF-083010 controls the biological activity of IRE1. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,412510,IRE1 Inhibitor I, STF-083010 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,412510,IRE1 Inhibitor I, STF-083010 - Calbiochem

    重要规格表

    经验配方
    C₁₅H₁₁NO₃S₂
    描述
    概述 A cell-permeable salicylidene compound that is shown to directly target Ireα1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60 µM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60 mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties.
    产品目录编号 412510
    品牌系列 Calbiochem®
    同义词 N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010
    参考
    参考 Lerner, A.G., et al. 2012 Cell Metabolism 16, 250.
    Papandreou, I., et al. 2010. Blood 117, )1311.
    产品信息
    形式 Yellow powder
    Hill配方 C₁₅H₁₁NO₃S₂
    化学配方 C₁₅H₁₁NO₃S₂
    Molar Mass 317.4
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Unstable in solution; reconstitute just prior to use.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,412510,IRE1 Inhibitor I, STF-083010 - Calbiochem

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