merck millipore,默克密理愽
  • merck millipore,默克密理博,385581,11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem

  • merck millipore,默克密理博,385581,11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem

    产品名称：11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem
    产品型号：385581
    The 11beta-HSD1 Inhibitor, 10j, also referenced under CAS 1009373-58-3, controls the biological activity of 11beta-HSD1. This small molecule/inhibitor is primarily used for Protease Inhibitors applica More>>

    merck millipore,默克密理博,385581,11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,385581,11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₆H₃₃BrN₂O₃1009373-58-3
    描述
    概述 A cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10mg/kg in animals p.o.) results in an ˜ 80% reduction in the concentration of plasma cortisol over vehicle treated controls.
    产品目录编号 385581
    品牌系列 Calbiochem®
    参考
    参考 Tice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.
    产品信息
    CAS号 1009373-58-3
    形式 White solid
    Hill配方 C₂₆H₃₃BrN₂O₃
    化学配方 C₂₆H₃₃BrN₂O₃
    Molar Mass 501.46
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

    merck millipore,默克密理博,385581,11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem

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