- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
经验配方 C₁₉H₂₂N₂O₃ 描述 概述 A cell-permeable, phenylbutyrate hydroxamate pan-HDAC inhibitor that is shown to suppress the activities of class I (HDAC1 and HDAC8), class II (HDAC4 and HDAC6), and class IV (HDAC11) HDACs by > ~90% compared to control, at a concentration of 1 µM with a comparable or greater inhibitory effect than SAHA. In vitro, this compound exhibits a broad spectrum of anti-tumor activities in NSCLC cells, holds synergistic effects with cisplatin in the reduction of cell viability, is implicated in the induction of the intrinsic apoptotic pathway, and displays inhibitory effects against mitosis and cytokinesis. This inhibitor is also shown to suppress tumor growth in mice genograft models by 62%, 78% and 90% at 7.5, 15 and 30 mg/kg respectively without adversely affect in body weight and detectable toxicity. 产品目录编号 382181 品牌系列 Calbiochem®
同义词 OSU-HDAC-44 参考 参考 Tang, Y., et al. 2010. PLoS One 5, e12417. 产品信息 形式 Off-white solid Hill配方 C₁₉H₂₂N₂O₃ 化学配方 C₁₉H₂₂N₂O₃ Molar Mass 326.39 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,04-372,Anti-Lck/p56 Antibody, clone Y123, rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,AB15614-50UL,Anti-CNGA3 Antibody
merck millipore,默克密理博,ZTSCXS096,ZipTip 微量层析柱，具有 0.6 µL 强阳离子交换树脂
merck millipore,默克密理博,SF-1354,CCND2; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,04-1054,Anti-S100-β (CT) Antibody, clone EP1576Y, rabbit monoclonal
merck millipore,默克密理博,648462,TRITON X-100 Detergent - CAS 9002-93-1 - Calbiochem
merck millipore,默克密理博,04-372,Anti-Lck/p56 Antibody, clone Y123, rabbit monoclonal
merck millipore,默克密理博,AB15614-50UL,Anti-CNGA3 Antibody
merck millipore,默克密理博,CP53,Anti-ICAM-1 (Ab-2) Mouse mAb (W-CAM-1)
merck millipore,默克密理博,0500-4130,GuavaSuite Software Modules for Guava easyCyte HT Systems
merck millipore,默克密理博,ABS1064,Anti-Hypusine Antibody Antibody
merck millipore,默克密理博,QIA87,Cytochrome c Release Apoptosis Assay Kit