merck millipore,默克密理博,361566,GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,361566,GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem
产品名称：GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem
产品型号：361566

merck millipore,默克密理博,361566,GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem

产品介绍

merck millipore,默克密理博,361566,GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem

重要规格表

经验配方	CAS号
C₁₉H₁₂Cl₂N₂O₂	280744-09-4

描述
概述	A cell-permeable (aryl,indole) maleimide compound that acts as a potent, selective, ATP-competitive inhibitor of GSK-3 activity (K_i = 9.1 nM for GSK-3α). At 10 µM concentration, does not significantly inhibit a panel of 24 other protein kinases tested. Reported to stimulate glycogen synthesis in Chang human liver cells (EC₅₀ = 3.6 µM) and induce transcription of β-catenin-LEF/TCF (lymphoid enhancer factor/T cell factor) regulated reporter gene in HEK293 human embryonic kidney cell lines. Offers protection against polyglutamine-induced death in SK-N-SH and COS-7 cells and attenuates hypoxia-induced apoptosis in VSMC and COS-7 cells. Shown to reduce phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) expression in hepatoma cells. Promotes the survival of CLL lymphocytes via Wnt/β-catenin-mediated transcription activation. Exhibits delayed cardioprotection in vivo in a rat model via a KATP (ATP-sensitive potassium channels) and MPTP (mitochondrial permeability transition pore)-dependent mechanism at reperfusion.
产品目录编号	361566
品牌系列	Calbiochem®
同义词	SB-216763

参考
参考	Gross, E., et al. 2008. Am. J. Phy. Heart Circ Physiol. 294, H1497. Bain, J., et al. 2007. Biochem. J. 408, 297. Lu, D., et al. 2004. PNAS. 101, 3118. Carmichael, J., et al. 2002. J. Biol. Chem. 277, 33791. Culbert, A.A., et al. 2001. FEBS Lett. 507, 288. Lochhead, P.A., et al. 2001. Diabetes 50, 937. Cross, D.A., et al. 2001. J. Neurochem. 77, 94. Coghlan, M.P., et al. 2000. Chem. Biol. 7, 793.

参考

Gross, E., et al. 2008. Am. J. Phy. Heart Circ Physiol. 294, H1497.
Bain, J., et al. 2007. Biochem. J. 408, 297.
Lu, D., et al. 2004. PNAS. 101, 3118.
Carmichael, J., et al. 2002. J. Biol. Chem. 277, 33791.
Culbert, A.A., et al. 2001. FEBS Lett. 507, 288.
Lochhead, P.A., et al. 2001. Diabetes 50, 937.
Cross, D.A., et al. 2001. J. Neurochem. 77, 94.
Coghlan, M.P., et al. 2000. Chem. Biol. 7, 793.

产品信息
CAS号	280744-09-4
形式	Orange solid
Hill配方	C₁₉H₁₂Cl₂N₂O₂
化学配方	C₁₉H₁₂Cl₂N₂O₂
Molar Mass	371.2
结构配方图像

生物信息
纯度	≥98% by HPLC

理化信息
溶解度	DMSO

安全信息
R相	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S相	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Irritant
储存	+2°C to +8°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.