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merck millipore,默克密理博,361549,GSK-3β Inhibitor VIII - CAS 487021-52-3 - Calbiochem
产品名称：GSK-3β Inhibitor VIII - CAS 487021-52-3 - Calbiochem
产品型号：361549
The GSK-3β Inhibitor VIII, also referenced under CAS 487021-52-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation ap More>>
merck millipore,默克密理博,361549,GSK-3β Inhibitor VIII - CAS 487021-52-3 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₂H₁₂N₄O₄S 487021-52-3 描述 概述 A cell-permeable thiazole-containing urea compound that acts as a potent inhibitor of GSK-3. Shown to inhibit GSK-3β with high potency (IC50 = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38 nM). Specificity has been reported using a panel of 28 different kinases, including Cdk2 and Cdk5 (IC50 > 100 µM). Shown to prevent tau phosphorylation at a GSK-3-specific site. Also shown to protect neuronal cells against Aβ-mediated neurodegeneration in vitro and reduce tauopathy in mice in vivo (30 µmol/kg delivered with 40% PEG400 and 40% dimethylacetamide in water). Caution: Do not use delivering vehicles containing dimethylamine for in vivo studies, as it is highly toxic to animals. A 25 mM (5 mg/649 µl) solution of GSK-3β Inhibitor VIII (Cat. No. 361557) in DMSO is also available. 产品目录编号 361549 品牌系列 Calbiochem®
同义词 AR-A014418, N-(4-Methoxybenzyl)-Nʹ-(5-nitro-1,3-thiazol-2-yl)urea 参考 参考 Noble, W., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 6990.
Bhat, R., et al. 2003. J. Biol. Chem. 278, 45937.产品信息 CAS号 487021-52-3 具有ATP竞争性 Y 形式 Yellow solid Hill配方 C₁₂H₁₂N₄O₄S 化学配方 C₁₂H₁₂N₄O₄S Molar Mass 308.3 可逆 N 结构配方图像 生物信息 主靶 Gsk-3β 主靶IC50 104 nM against GSK-3β 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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