merck millipore,默克密理愽
  • merck millipore,默克密理博,361540,GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem

  • merck millipore,默克密理博,361540,GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem

    产品名称：GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem
    产品型号：361540
    The GSK-3β Inhibitor I, also referenced under CAS 327036-89-5, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appli More>>

    merck millipore,默克密理博,361540,GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,361540,GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₀H₁₀N₂SO₂327036-89-5
    描述
    概述 A thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 µM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 > 100 µM). Binds to the active site of GSK-3β.
    产品目录编号 361540
    品牌系列 Calbiochem®
    同义词 TDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
    参考
    参考 Guzman, M.L., et al. 2007. Blood 110, 4436.
    Barry, F.A., et al. 2003. FEBS Lett. 553, 173.
    Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.
    产品信息
    CAS号 327036-89-5
    具有ATP竞争性 N
    形式 White to off-white solid
    Hill配方 C₁₀H₁₀N₂SO₂
    化学配方 C₁₀H₁₀N₂SO₂
    Molar Mass 222.3
    可逆 N
    结构配方图像
    生物信息
    主靶 Gsk-3β
    主靶IC50 2 µM, 673 nM, 1.4-5.5 µM, against GSK-3β, Flt-3, and PKC activities, respectively
    纯度 ≥ 95% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,361540,GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,401020,Imiquimod - CAS 99011-02-6 - Calbiochem


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