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merck millipore,默克密理博,324878,Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem
产品名称：Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem
产品型号：324878
The Focal Adhesion Kinase Inhibitor II, also referenced under CAS 869288-64-2, controls the biological activity of Focal Adhesion Kinase. This small molecule/inhibitor is primarily used for Phosphoryl More>>
merck millipore,默克密理博,324878,Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₂H₂₀F₃N₅O₃S 869288-64-2 描述 概述 A cell-permeable pyrimidinyldiamino compound that acts as a selective, ATP-competitive, and potent FAK inhibitor (IC50 = 4 nM). It inhibits CDK7/cycH/MAT1 and CDK1/cycB only at much higher concentrations (IC50 = 197 and 486 nM, respectively) and exhibits little or much reduced activity against 39 other commonly studied kinases (≤64% inhibition at 1 µM). PF-573,228 effectively inhibits cellular FAK Tyr397 phosphorylation in various human, rat, and canine cell lines (IC50 = ~30-500 nM during an 1 h incubation period) and concomitant blockage of Tyr31 phosphorylation of the FAK downstream substrate paxillin is also demonstrated in rat fibroblast REF52 cultures. A useful tool for studying FAK-mediated cellular functions. 产品目录编号 324878 品牌系列 Calbiochem®
同义词 PF-573,228, PF-228, 6-((4-((3-(Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino)-3,4-dihydro-1H-quinolin-2-one, FAK Inhibitor II, Cdk7 Inhibitor V 参考 参考 Slack-Davis, J.K., et al. 2007. J. Biol. Chem. 282, 14845. 产品信息 CAS号 869288-64-2 形式 Off-white solid Hill配方 C₂₂H₂₀F₃N₅O₃S 化学配方 C₂₂H₂₀F₃N₅O₃S Molar Mass 491.5 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO 安全信息 S相 S: 22-24/25-36/37/39
Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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