merck millipore,默克密理愽
  • merck millipore,默克密理博,324623,Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem

  • merck millipore,默克密理博,324623,Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem

    产品名称：Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem
    产品型号：324623
    The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,324623,Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324623,Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₄H₁₁FN₂OS909250-29-9
    描述
    概述 A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.
    产品目录编号 324623
    品牌系列 Calbiochem®
    同义词 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione
    参考
    参考 Muller, C., et al. 2007. Cancer Chemother. Pharmacol. 59, 157.
    Santamaria, A., et al. 2007. Mol. Biol. Cell 18, 4024.
    Sarli, V., et al. 2005. ChemBioChem 6, 2005.
    产品信息
    CAS号 909250-29-9
    形式 White solid
    Hill配方 C₁₄H₁₁FN₂OS
    化学配方 C₁₄H₁₁FN₂OS
    Molar Mass 274.3
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,324623,Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem

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