merck millipore,默克密理愽
  • merck millipore,默克密理博,324410,Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

  • merck millipore,默克密理博,324410,Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

    产品名称：Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem
    产品型号：324410
    The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

    merck millipore,默克密理博,324410,Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324410,Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₄N₂O₄304448-55-3
    描述
    概述 A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.
    产品目录编号 324410
    品牌系列 Calbiochem®
    同义词 3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin
    参考
    参考 Young, A., et al. 2009. Biochem. J. , In press.
    Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
    Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
    Macia. E., et al. 2006. Dev. Cell 10, 839.
    产品信息
    CAS号 304448-55-3
    形式 Pale yellow solid
    Hill配方 C₁₈H₁₄N₂O₄
    化学配方 C₁₈H₁₄N₂O₄
    Molar Mass 322.3
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    安全信息
    R相 R: 50

    Very toxic to aquatic organisms.
    S相 S: 22-24/25

    Do not breathe dust.
    Avoid contact with skin and eyes.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Environmental Hazard
    有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,324410,Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

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