merck millipore,默克密理博,265005,Dexamethasone - CAS 50-02-2

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,265005,Dexamethasone - CAS 50-02-2 - Calbiochem
产品名称：Dexamethasone - CAS 50-02-2 - Calbiochem
产品型号：265005
Most active and highly stable glucocorticoid.

merck millipore,默克密理博,265005,Dexamethasone - CAS 50-02-2 - Calbiochem

产品介绍

merck millipore,默克密理博,265005,Dexamethasone - CAS 50-02-2 - Calbiochem

重要规格表

经验配方	CAS号
C₂₂H₂₉FO₅	50-02-2

描述
概述	Most active and highly stable glucocorticoid. Causes a reduction in cyclin A and Cdk2 activity, and inhibition of G₁/S transition in osteoblasts. Inhibits the phosphorylation of retinoblastoma (Rb) protein. Inhibits the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells (IC₅₀ = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na⁺ - K⁺ pump. Induces apoptosis in human thymocytes.
产品目录编号	265005
品牌系列	Calbiochem®
同义词	9α-Fluoro-16α-methylprednisolone

参考
参考	Reil, T.D., et al. 2000. J. Surg. Res. 92, 108. Smith, E., et al. 2000. J. Biol. Chem. 275, 1992. Petit, P.X., et al. 1995. J. Cell Biol. 130, 157. Stern, N., et al. 1994. Am. J. Hypertens. 7, 146. Donis, J.A., et al. 1993. Biotechniques 15, 786. Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916. Sarin, A., et al. 1993. J. Exp. Med. 178, 1693. Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383. Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341. Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505. Warters, R.L. 1992. Cancer Res. 52, 883. Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490. Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043. Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.

参考

Reil, T.D., et al. 2000. J. Surg. Res. 92, 108.
Smith, E., et al. 2000. J. Biol. Chem. 275, 1992.
Petit, P.X., et al. 1995. J. Cell Biol. 130, 157.
Stern, N., et al. 1994. Am. J. Hypertens. 7, 146.
Donis, J.A., et al. 1993. Biotechniques 15, 786.
Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383.
Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341.
Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505.
Warters, R.L. 1992. Cancer Res. 52, 883.
Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490.
Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043.
Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.

产品信息
CAS号	50-02-2
具有ATP竞争性	N
形式	White solid
Hill配方	C₂₂H₂₉FO₅
化学配方	C₂₂H₂₉FO₅
Molar Mass	392.5
可逆	N
结构配方图像

生物信息
主靶	Phosphorylation of rb protein
主靶IC₅₀	5 nM Inhibiting the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells
纯度	≥99% by TLC

理化信息
细胞可渗透	N
溶解度	DMSO, CHCl₃ or EtOH

GHS安全信息
RTECS	TU3980000

安全信息
R相	R: 36/37/38-43-63 Irritating to eyes, respiratory system and skin. May cause sensitization by skin contact. Possible risk of harm to the unborn child.
S相	S: 24-26-36/37 Avoid contact with skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Carcinogenic / Teratogenic
储存	+2°C to +8°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.