merck millipore,默克密理博,239802,Curcumin, Curcuma longa L. - CAS 458-37-7

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merck millipore,默克密理博,239802,Curcumin, Curcuma longa L. - CAS 458-37-7 - Calbiochem
产品名称：Curcumin, Curcuma longa L. - CAS 458-37-7 - Calbiochem
产品型号：239802
A cell-permeable and irreversible antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC₅₀ = 8 µM) and cyclooxygenase (IC₅₀ = 52 µM).

merck millipore,默克密理博,239802,Curcumin, Curcuma longa L. - CAS 458-37-7 - Calbiochem

产品介绍

merck millipore,默克密理博,239802,Curcumin, Curcuma longa L. - CAS 458-37-7 - Calbiochem

重要规格表

经验配方	CAS号
C₂₁H₂₀O₆	458-37-7

描述
概述	A cell-permeable and irreversible antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC₅₀ = 8 µM) and cyclooxygenase (IC₅₀ = 52 µM). Confers significant protection against neurotoxic and genotoxic agents. Also inhibits the induction of nitric oxide synthase in activated macrophages (IC₅₀ = 6 µM). Recently shown to inhibit the EGF receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells in a dose- and time-dependent manner. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC₅₀ of ~25 µM. Does not affect p300/CREB binding protein-associated factor (PCAF).
产品目录编号	239802
品牌系列	Calbiochem®
同义词	1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Histone Acetyltransferase Inhibitor I, HAT Inhibitor I, p300/CBP Inhibitor I, NOD2 Signaling Inhibitor I, Nucleotide-binding Oligomerization Domain 2 Signaling Inhibitor I

参考
参考	Hung, S., et al. 2008. Mol. Pharmacol. 74, 274. Cui, L., et al. 2007. Antimicrob. Agents Chemother. 51, 488. Salvioli, S., et al. 2007. eCAM 4, 181. Balasubramanyam, K. et al. 2004. J. Biol. Chem. 279, 51163. Brouet, I., and Okshima, H. 1995. Biochem. Biophys. Res. Commun. 206, 533. Korutla, L., and Kumar, R. 1994. Biochim. Biophys. Acta 1224, 597. Flynn, D.L., et al. 1986. Prostagland. Leuk. Med. 22, 357.

参考

Hung, S., et al. 2008. Mol. Pharmacol. 74, 274.
Cui, L., et al. 2007. Antimicrob. Agents Chemother. 51, 488.
Salvioli, S., et al. 2007. eCAM 4, 181.
Balasubramanyam, K. et al. 2004. J. Biol. Chem. 279, 51163.
Brouet, I., and Okshima, H. 1995. Biochem. Biophys. Res. Commun. 206, 533.
Korutla, L., and Kumar, R. 1994. Biochim. Biophys. Acta 1224, 597.
Flynn, D.L., et al. 1986. Prostagland. Leuk. Med. 22, 357.

产品信息
CAS号	458-37-7
具有ATP竞争性	N
形式	Orange-yellow solid
Hill配方	C₂₁H₂₀O₆
化学配方	C₂₁H₂₀O₆
Molar Mass	368.4
可逆	N
结构配方图像

生物信息
主靶	5-lipoxygenase
主靶IC₅₀	8 µM, 52 µM, against 5-lipoxygenase, Cyclooxygenase, respectively; 6 µM inhibiting the induction of nitric oxide synthase in activated macrophages
纯度	≥80% by HPLC

理化信息
细胞可渗透	Y
溶解度	Acetic Acid or DMSO

GHS安全信息
RTECS	MI5230000

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+15°C to +30°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.