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描述 概述 Recombinant, human C5a complement (74 amino acids) fused at the N-terminus to a His•Tag® sequence and a proprietary vector sequence necessary for expression and expressed in E. coli. The recombinant protein is not further processed to remove the additional sequence. Activation of complement by either pathway results in the formation of C5-cleaving enzymes (C5 convertases) on target surfaces. The C5 convertase enzymes cleave the C5 α-chain at peptide bond 74 resulting in the production and release of the C5a glycopeptide. C5a is the most biologically active of the three complement-derived anaphylatoxins. C5a expresses a wide variety of biogical activities which include: inflammatory cell chemotaxis, smooth muscle contraction, and release reactions of neutrophils, mast cells, and macrophages.
Available in Bulk - request a quote!产品目录编号 234397 品牌系列 Calbiochem®
参考 参考 Carney, D.F. and Hugli, T.E. 1993. Protein Sci. 2, 1391.
Hugli, T.E., et al. 1981. Mol. Cell. Biochem. 41, 59.产品信息 形式 Lyophilized solid Molar Mass 11200 生物信息 生物活性 Exhibits equal activity to that of serum-derived C5a based on a myeloperoxidase release assay. 纯度 ≥95% by SDS-PAGE 理化信息 污染物 Endotoxins: ≤0.1 ng/µg protein 溶解度 dH₂O 储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
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