merck millipore,默克密理博,23-028,IkBa Protein, activated, 10 µg

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Merck Millipore 默克密理愽

主要应用	品种	级联部件
EA	Human	Substrate

描述
产品目录编号	23-028
品牌系列	Upstate
商名	Upstate
描述	IkBa Protein, activated, 10 µg
长描述	N-terminal c-Myc, 6His-tagged, recombinant human IκBα full length, expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography. Phosphorylated in vitro using IKKα, active (Item # 14-461)
Alternate Names	Major histocompatibility complex enhancer-binding protein MAD3 NF-kappa-B inhibitor alpha I-kappa-B-alpha
背景信息	IκBα is a cellular protein that inhibits the transcription factor NF-κB. NF-κB plays a central role in cellular stress and inflammatory responses by controlling cytokine-inducible gene expression and lymphocyte stimulation by antigens. In non-stimulated cells NF-κB is sequestered in the cytoplasm via the inhibitory protein IκBα, which obscures the nuclear localization signal of NF-κB and also blocks its ability to bind DNA. In response to various stimuli, including viral infection, ultraviolet radiation and inflammatory cytokines, IκBα is phosphorylated by the protein kinase complex IKK, which triggers its rapid degradation by ubiquitin mediated proteolysis. The liberated NF-κB then translocates to the nucleus and activates the expression of target genes. Mutations in the gene for IκBα result in the functional impairment of NF-κB which causes a decreased production of proinflammatory cytokines and certain interferons, rendering patients susceptible to infection.

应用
应用	Activated, full length, recombinant human IκBα. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using IKKα, active. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.
主要应用	Enzyme Assay

生物信息
品种	Human
特异活性	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
级联部件	Substrate
Entrez基因编号	M69043 (GenBank Number)
纯化方法	Purified using immobilized metal affinity chromatography.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

包装信息
数量	10 µg

merck millipore,默克密理博,23-028,IkBa Protein, activated, 10 µg

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